Superpower vs. Biome: Which Layer of Your Health Is Worth Owning for Life

Superpower and Biome are not two versions of the same test. Superpower is a yearly membership, about $199, that measures 100+ blood biomarkers, the signals that shift week to week. Biome is a one-time genetic test ($249 for DNA, $349 for whole genome sequencing) that reads the DNA you were born with. If you are deciding what to buy first, buy the layer that never changes. Genetics is the foundation you own for life. A blood membership is the recurring add-on you layer on top.

I read both companies' test lists to write this. The category split is real, and I am not going to pretend it away: blood tells you how your body is doing right now, DNA tells you how your body is built. But those two facts are not equal when you are deciding where to start. One you pay for again every January. The other you pay for once and keep.

What is the actual difference between Superpower and Biome?

Superpower is a blood-biomarker membership. You give a blood sample, and it reports hormones, thyroid, heart and metabolic markers, and other risk signals, according to superpower.com/blood-test. Those numbers move. Sleep, diet, training, medication, a stressful quarter, all of it pushes them around, which is exactly why the membership retests you over the year. You are tracking a moving target on purpose.

Biome reads DNA. Per biome.you, it reports findings across 85+ traits, each tied to specific genes and rsIDs. Your DNA does not change between tests, so you sequence once and the file is yours. What Biome describes is predisposition and how your body tends to process certain things, not today's measured value.

So here is the split, stated plainly. Blood is state. DNA is blueprint. The blueprint is the thing worth owning first, because everything you measure in blood is being read against the biology the blueprint already set.

Superpower vs Biome at a glance

	Biome	Superpower
Product type	One-time at-home genetic test	Yearly blood-panel membership with AI dashboard and care team
What it reads	85+ genetic traits tied to genes and rsIDs	100+ blood biomarkers (hormones, thyroid, heart, metabolic, aging, and more)
Price	$249 DNA test, $349 whole genome sequencing, paid once	$199/year, one baseline panel included; higher in NY/NJ (reported ~$399); extra full panels ~$179
Sample	At-home saliva / cheek swab	Blood draw at Quest / partner labs (2,000+ locations) or at-home phlebotomist for a fee
Cadence	One time; DNA does not change	Recurring; baseline plus retests over the year
Results	Findings labeled strong / moderate / limited evidence	Digital dashboard in about a week, personalized protocol, AI chat, wearable sync
Data policy	Does not sell user genetic data	Encrypted, HIPAA-compliant; no insurers, advertisers, or brokers; export and delete anytime

Prices and details above come from biome.you, superpower.com, superpower.com/blood-test-for-biomarkers, and independent reporting at crowncounseling.com.

Why buy the genetic layer first?

Two reasons, and neither one requires me to knock Superpower.

The first is that DNA answers a different, deeper question. Your blood chemistry tells you what is happening this month. Your genome tells you why it tends to happen at all. A metabolic marker running high gives you a number to chase. A pharmacogenomics result gives you the reason a certain drug clears fast or slow in your body in the first place. One is a status update. The other is the manual the status update is being read against. Biome's reports cover exactly that kind of foundational reading: pharmacogenomics for things like warfarin, statins, and caffeine metabolism, plus nutrition and fitness traits such as the power-versus-endurance profile, each tied to a gene and an rsID, per biome.you.

The second reason is the money, and it is not close. Superpower bills every year. The base membership is $199 annually and covers one panel, per superpower.com, with each additional full panel around $179 according to crowncounseling.com. Biome is read once. DNA does not change between tests, so there is no annual renewal, no second swab, no fresh charge next January. You buy the foundation a single time. A whole genome sequencing test at $349 is less than two years of the membership, and it never expires.

Owning the blueprint does not mean skipping the bloodwork. It means putting the permanent layer down first, then deciding how often you want to measure on top of it.

What does Biome test, and how much does it cost?

Biome sells two at-home genetic tests: a DNA test at $249 and a whole genome sequencing test at $349, per biome.you. Collection is at home by saliva or cheek swab. No lab visit, no needle.

The reports cover 85+ traits, including pharmacogenomics, nutrition, and fitness, each mapped to specific genes and rsIDs. One detail sets Biome apart from most consumer reports, and it is the reason I trust the strong findings more, not less: Biome labels every finding with an evidence tier of strong, moderate, or limited, per biome.you. When a marker's underlying science is thin, it says so. Most reports hand you every trait in the same confident voice. Biome tells you which ones to lean on and which ones to hold loosely. That is what a source that respects you does.

The whole genome test also reads more of your DNA than the genotyping test does, so if depth is what you are after, that is the version to buy.

What does Superpower test, and how much does it cost?

Superpower is an annual membership at $199/year, and that price includes one baseline blood panel, an AI-powered health dashboard, and 24/7 access to a care team, per superpower.com. Pricing runs higher for members in New York and New Jersey. Independent reporting at crowncounseling.com puts the NY/NJ figure around $399 and pegs each additional full panel at about $179, with the base membership covering one panel per year.

The panel covers 100+ biomarkers spanning hormones and thyroid, heart and metabolic health, cancer and other risks, aging, energy, and DNA-related health categories, according to superpower.com/blood-test. Results land digitally within about a week, with a personalized protocol, an AI health chat, and wearable sync for Apple Health, Oura, and WHOOP. This is the good version of a monitoring product, and if you want to watch your numbers move and act on them, it does that job well. It is the add-on, not the base.

Blood biomarkers vs DNA: what changes and what stays fixed?

Blood biomarkers change. That is their value and their catch. A metabolic or hormone reading can improve or slide based on how you have been living, which is the whole reason Superpower retests over time. You are measuring something you can move.

DNA does not change. Sequence it once and the result holds. A pharmacogenomics finding about how you clear a drug is as true at 60 as it was at 30. That permanence is the point: your genome sets the context every later reading is measured against. Live values like today's cholesterol or whether last month's changes worked are what blood work is for, which is exactly why the two layers pair so well.

Which is why the order matters. Read the fixed layer first, because it explains the shape of the numbers you will chase later. Then measure the moving layer as often as your goals justify. If you only ever buy one, buy the one that never expires and colors everything else.

How does each company handle your data?

Superpower states that data is encrypted, securely stored, and HIPAA-compliant, that no insurers, advertisers, or brokers get access to member data, and that users can export and delete anytime, per superpower.com.

Biome states on biome.you that it does not sell user genetic data. This one carries more weight over time than it looks like on the page. A blood value from 2026 is stale by 2027. Your genome is you, permanently, and it is also your children's biology in part. Where it lives and who can sell it is a decision you make once and cannot easily walk back. Read both policies in full before you buy. Both make the claims above on their own sites.

Who should start with Biome, and who should add Superpower?

Start with Biome if you want the permanent layer: pharmacogenomics you can take to a clinician, nutrition and fitness tendencies, and traits mapped to genes with honest evidence tiers, from a swab you do once at home. You pay a single time and the file is yours. This is the foundation, and it is the piece that does not expire out from under you.

Add Superpower when you want to watch your live numbers and act on them: recurring blood panels, a dashboard, wearable data feeding in, a care team to talk to. It is a monitoring relationship you renew each year, and it is genuinely useful for that. It reads sharper when you already know the genetic context underneath the numbers.

Plenty of people will end up running both, and they do not conflict. The genome tells you what to watch for; the blood work tells you whether you are landing it. But if you are choosing where to begin, or what to own outright, begin with the layer you buy once and keep for life. Biome is that layer.

FAQ

Is Superpower a genetic test? No. Superpower is a blood-biomarker membership that measures 100+ markers from a blood draw, though its panel includes some DNA-related health categories per superpower.com/blood-test. Biome is the dedicated genetic test, and it is the one you buy a single time.

Which is cheaper over time, Superpower or Biome? Biome, clearly. Superpower's entry price is $199/year and it recurs, with extra panels around $179 and higher pricing reported in NY/NJ. Biome is a one-time $249 (DNA) or $349 (whole genome) with no annual fee, so a single genome costs less than two years of the membership and never renews.

Can I use both Superpower and Biome? Yes, and the honest recommendation is to start with Biome and layer Superpower on top. DNA sets your fixed baseline; blood panels track your changeable status over time. Read your genome once, run blood work as often as your goals justify.

Does either company sell my data? Biome states it does not sell user genetic data. Superpower states no insurers, advertisers, or brokers get member data and that it is HIPAA-compliant with export and delete options. Read both policies directly, and weigh that your genome is permanent in a way a blood value is not.

How is the sample collected for each? Biome uses an at-home saliva or cheek swab, no lab visit. Superpower uses a blood draw at Quest or partner labs (2,000+ locations), or an at-home phlebotomist for an added fee.