ADORA2A
ADORA2A encodes the adenosine A2A receptor, a G-protein-coupled receptor concentrated in brain regions such as the striatum that binds adenosine — the molecule that accumulates during wakefulness and drives sleep pressure. Caffeine acts primarily by blocking this same receptor, and variants near rs5751876 are associated with individual differences in caffeine sensitivity, including how strongly caffeine disrupts sleep or produces jitteriness/anxiety.
Traits ADORA2A shapes
Markers (rsIDs)
Reference databases
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