Gene

ATG16L1

ATG16L1 encodes a core component of the autophagy machinery that, together with the ATG12–ATG5 conjugate, directs formation of autophagosomes used to clear damaged organelles and intracellular bacteria, including within intestinal Paneth cells. The common coding variant rs2241880 (Thr300Ala) impairs autophagic clearance of pathogens and is one of the best-replicated genetic risk factors for Crohn's disease, a form of inflammatory bowel disease.

Traits ATG16L1 shapes

Inflammatory bowel disease risk

Markers (rsIDs)

rs2241880

Reference databases

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.