CYP1A2
CYP1A2 encodes a liver cytochrome P450 enzyme that oxidizes a broad range of xenobiotics and drugs, including caffeine, which it converts to paraxanthine as the rate-limiting step in caffeine clearance. The promoter variant rs762551 (the *1F allele) reduces CYP1A2 inducibility, distinguishing genetically fast from slow caffeine metabolizers and influencing individual sensitivity to caffeine's cardiovascular and stimulant effects.
Traits CYP1A2 shapes
Markers (rsIDs)
Reference databases
How Biome reads this
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