CYP2B6
CYP2B6 encodes a hepatic cytochrome P450 enzyme that metabolizes a range of clinically important drugs, including the antiretroviral efavirenz, the chemotherapy prodrug cyclophosphamide, the antidepressant bupropion, and the opioid methadone. Common CYP2B6 variants (such as the reduced-function *6 allele) slow efavirenz clearance, raising plasma drug levels and the risk of central nervous system side effects, which is why the gene is used as pharmacogenomic context for CYP2B6 substrate drugs.
Traits CYP2B6 shapes
Reference databases
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