CYP2C19
CYP2C19 encodes a hepatic cytochrome P450 enzyme that metabolizes numerous widely used drugs, including proton-pump inhibitors like omeprazole, several SSRI antidepressants such as citalopram and escitalopram, and the antiplatelet prodrug clopidogrel, which requires CYP2C19-mediated activation to its active metabolite. Common loss-of-function alleles (e.g., *2, *3) produce poor-metabolizer phenotypes that reduce clopidogrel efficacy and slow clearance of other CYP2C19 substrates, making the gene central to pharmacogenomic dosing guidance for these drug classes.
Traits CYP2C19 shapes
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.