CYP2D6
CYP2D6 encodes a highly polymorphic hepatic cytochrome P450 enzyme that metabolizes an estimated 20-25% of commonly prescribed drugs, including many antidepressants and antipsychotics, opioid analgesics such as codeine and tramadol, and beta blockers. Its activity is shaped not only by single-nucleotide variants but also by gene copy-number changes and hybrid/deletion alleles, so accurate phenotype prediction (poor, intermediate, normal, or ultrarapid metabolizer) generally requires whole-genome-level structural variant calling rather than a handful of SNPs.
Traits CYP2D6 shapes
Reference databases
How Biome reads this
This needs whole genome sequencing — it reads structural and copy-number detail a genotyping array can't reliably see.
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