CYP3A5
CYP3A5 encodes a cytochrome P450 enzyme closely related to CYP3A4 that is expressed in liver and intestine and contributes to the metabolism of drugs such as the immunosuppressant tacrolimus. A common variant (CYP3A5*3) abolishes functional protein expression; individuals who carry at least one functional CYP3A5*1 allele are classified as CYP3A5 "expressers" and metabolize tacrolimus faster, requiring higher doses to reach therapeutic blood levels, which is why CYP3A5 genotype is used clinically to guide tacrolimus dosing.
Traits CYP3A5 shapes
Reference databases
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