Gene

FOXO3

FOXO3 encodes Forkhead box O3, a transcription factor acting downstream of insulin and IGF-1 signaling that activates genes governing oxidative-stress resistance, DNA repair, apoptosis, and cell-cycle arrest. It is one of the most consistently replicated genes associated with human longevity across independent populations. The variant rs2802292 in FOXO3 is a well-studied marker linked to exceptional lifespan and healthy aging.

Traits FOXO3 shapes

FOXO3 longevity variant

Markers (rsIDs)

rs2802292

Reference databases

HGNC gene symbol report: FOXO3
NCBI Gene: FOXO3

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.