GBA
GBA (glucosylceramidase beta) encodes a lysosomal enzyme that hydrolyzes glucosylceramide into glucose and ceramide as part of normal lipid recycling in cells; biallelic loss-of-function mutations cause Gaucher disease. Heterozygous GBA variants are among the strongest known genetic risk factors for Parkinson's disease, thought to act through impaired lysosomal degradation and accumulation of alpha-synuclein in neurons.
Traits GBA shapes
Markers (rsIDs)
Reference databases
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