IL23R
IL23R encodes the interleukin-23 receptor, a cell-surface receptor expressed on T helper 17 (Th17) cells, natural killer cells, and other immune cells that, together with IL12RB1, transmits IL-23 signaling via the JAK2/TYK2-STAT3 pathway to sustain Th17-driven inflammation. The rs11209026 variant (a protective missense change) is one of the most robustly replicated genetic associations with inflammatory bowel disease, altering IL-23 signaling strength and reducing risk for Crohn's disease and ulcerative colitis.
Traits IL23R shapes
Markers (rsIDs)
Reference databases
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