LCT
LCT encodes lactase-phlorizin hydrolase, the brush-border enzyme in the small intestine that hydrolyzes dietary lactose into glucose and galactose for absorption; enzyme activity normally declines after weaning in most mammals. The rs4988235 variant lies in a regulatory element upstream of LCT (within intron 13 of MCM6) that controls whether lactase expression persists into adulthood, determining lactose-digestion capacity, and this same regulatory region also influences ABO/FUT2-independent gut-microbiome composition patterns tied to dairy metabolism.
Traits LCT shapes
Markers (rsIDs)
Reference databases
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