PITX2
PITX2 (paired-like homeodomain transcription factor 2) encodes a homeodomain transcription factor essential for establishing left-right asymmetry during embryonic development and for normal formation of the heart, eye, and pituitary gland. In the adult heart, PITX2 is expressed in cardiomyocytes of the left atrium and pulmonary veins, where it suppresses a sinus-node-like (pacemaker) gene program; regulatory variants near PITX2 such as rs2200733 on chromosome 4q25 are among the strongest and most replicated genetic associations with atrial fibrillation.
Traits PITX2 shapes
Markers (rsIDs)
Reference databases
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