PSMA1
PSMA1 (proteasome 20S subunit alpha 1) encodes one of the alpha subunits of the 20S core proteasome, the barrel-shaped complex that degrades ubiquitin-tagged and misfolded proteins in nearly every cell. PSMA1 sits in a chromosome-11 locus (alongside CYP2R1, the enzyme that performs the first hydroxylation step in vitamin D activation) that GWAS of circulating 25-hydroxyvitamin D repeatedly flag, making it a marker for genetically influenced vitamin D response rather than a direct actor in the vitamin D pathway itself.
Traits PSMA1 shapes
Reference databases
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