SLCO1B1
SLCO1B1 encodes OATP1B1, a transporter on the liver-facing (basolateral) membrane of hepatocytes that pulls drugs, including statins, out of the bloodstream and into the liver for metabolism and clearance. Reduced-function SLCO1B1 variants slow this hepatic uptake, raising circulating statin concentrations and increasing the risk of statin-associated muscle symptoms, most notably with simvastatin.
Traits SLCO1B1 shapes
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.