TCF7L2
TCF7L2 encodes transcription factor 7-like 2, a transcriptional effector of the Wnt signaling pathway that regulates pancreatic islet cell development, proglucagon gene expression, and insulin secretion. The intronic variant rs7903146 is the single strongest common-variant genetic risk factor for type 2 diabetes identified in genome-wide association studies, acting by impairing insulin secretion and glucose homeostasis.
Traits TCF7L2 shapes
Markers (rsIDs)
Reference databases
How Biome reads this
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