TNF
TNF encodes tumor necrosis factor (TNF-alpha), a pro-inflammatory cytokine produced mainly by activated macrophages and other immune cells that signals through TNFR1/TNFR2 to drive inflammation, immune cell activation, fever, and apoptosis. The promoter variant rs1800629 (-308G>A) is associated with altered TNF transcription and has been studied extensively as a marker of baseline inflammatory-signaling tone and susceptibility to inflammatory and autoimmune conditions.
Traits TNF shapes
Markers (rsIDs)
Reference databases
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