rs10490924
rs10490924 is a missense variant in ARMS2 (c.205G>T), causing the Ala69Ser substitution, and sits on a haplotype at chromosome 10q26 alongside an HTRA1 promoter variant. It is one of the two strongest genetic risk factors for age-related macular degeneration identified in genome-wide studies, with homozygous carriers of the risk allele showing several-fold higher odds of AMD, particularly the neovascular and reticular pseudodrusen subtypes.
Traits rs10490924 reads
Gene
Reference databases
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