rs10818854
rs10818854 is an intronic variant in DENND1A, a gene whose theca-cell-specific splice isoform (DENND1A.V2) upregulates CYP17A1 and CYP11A1 expression to increase ovarian androgen biosynthesis. Multiple genome-wide and candidate-gene studies, primarily in Asian cohorts, associate the variant allele with increased risk of polycystic ovary syndrome, though replication has been inconsistent in some other ancestries.
Traits rs10818854 reads
Gene
Reference databases
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