rs10830963
rs10830963 is an intronic variant in MTNR1B, the gene encoding melatonin receptor 1B, which is expressed in pancreatic beta cells. The minor G allele is the strongest common variant associated with fasting plasma glucose and type 2 diabetes risk at this locus, acting through impaired glucose-stimulated insulin secretion rather than a coding change. In this dataset it is used as a circadian sub-signal for fasting glucose and sensitivity to late-night eating, alongside the broader type 2 diabetes polygenic risk score.
Traits rs10830963 reads
Gene
Reference databases
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