rs13405728
rs13405728 is an intronic variant in LHCGR, the gene encoding the luteinizing hormone/choriogonadotropin receptor that mediates LH and hCG signaling in ovarian follicles. It was identified in a Chinese genome-wide association study as a polycystic ovary syndrome (PCOS) susceptibility locus, where the G allele was more frequent in unaffected controls (protective) and the A allele more frequent in cases; this association was not replicated in a European-ancestry cohort. Its precise effect on LHCGR expression or receptor function has not been established, so it functions here as a population-specific PCOS risk marker rather than a proven causal variant.
Traits rs13405728 reads
Gene
Reference databases
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