rs16969968
rs16969968 is a missense variant in CHRNA5 producing an aspartate-to-asparagine substitution at codon 398 (Asp398Asn) in the alpha-5 subunit of the neuronal nicotinic acetylcholine receptor. The variant alters receptor calcium permeability and signaling, and largely co-occurs with a low-expression CHRNA5 haplotype, together blunting the receptor-mediated aversive/inhibitory response to nicotine exposure. This reduced feedback is associated with heavier smoking and increased nicotine dependence risk.
Traits rs16969968 reads
Gene
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.