rs2769264

rs2769264 is a common variant near SELENBP1 (selenium-binding protein 1), a gene encoding a copper-dependent thiol oxidase enzyme. In a genome-wide association study of erythrocyte trace-element levels, this variant reached genome-wide significance for blood copper concentration, with the G allele associated with higher copper levels; together with rs1175550 it explains roughly 4% of copper-level variance. It is used alongside CP rs35691438 (ceruloplasmin) as a marker of genetically influenced copper status, though replication of this specific association across cohorts has been limited.