rs35691438

rs35691438 is a common single-nucleotide variant located roughly 2 kb upstream of CP on chromosome 3, the gene encoding ceruloplasmin, the major copper-carrying protein in blood plasma and a protein expressed predominantly in liver. It is a non-coding, gene-proximal variant identified in a genome-wide association study of blood metal levels, where it reached genome-wide significance for serum copper concentration, consistent with a regulatory effect on CP expression rather than a change to the ceruloplasmin protein itself. In this dataset it is used with SELENBP1 rs2769264 to inform genetic tendency toward lower, typical, or higher circulating copper.