rs3798220
rs3798220 is the LPA Ile1891Met (p.Ile1891Met, also called I4399M) missense variant in the protease-like domain of apolipoprotein(a), a low-frequency coding change (about 2% allele frequency) in the LPA gene. The Met1891 variant tracks with a smaller kringle IV type-2 repeat isoform of apo(a) and drives markedly elevated plasma lipoprotein(a), roughly 8-fold higher in heterozygotes and 15-fold higher in homozygotes versus non-carriers, in Europeans (this association is not seen in East/Southeast Asians). Elevated Lp(a) from this variant is an independent, largely genetically-determined contributor to coronary artery disease risk and is used alongside LPA rs10455872, 9p21 rs1333049, and PCSK9 rs11591147 in polygenic CAD risk scoring.
Traits rs3798220 reads
Gene
Reference databases
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