rs4795399
rs4795399 is an intronic SNP in GSDMB that falls within a DNase-hypersensitive regulatory region inside the 17q21 linkage-disequilibrium block spanning GSDMB and ORMDL3, indicating a likely effect on expression of these neighboring genes rather than on protein sequence. Each copy of the risk allele has been associated with earlier average age of asthma onset, part of the broader, heavily replicated 17q21 asthma-susceptibility haplotype that raises airway-epithelial ORMDL3/GSDMB expression. It is one of the variants folded into the asthma and allergic disease polygenic risk score used in this dataset, alongside IL33 rs992969 and IL1RL1 rs72823641.
Traits rs4795399 reads
Gene
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.