rs6259
rs6259 is a missense variant in exon 8 of the SHBG gene (Asp327Asn, also numbered Asp356Asn depending on whether the signal peptide is counted) that introduces a new N-linked glycosylation site in the laminin G-like domain of sex hormone-binding globulin. The extra glycosylation does not change SHBG's steroid-binding affinity but slows its clearance from the bloodstream, so the Asn allele is associated with higher circulating SHBG levels. Because SHBG binds and limits the free, bioavailable fraction of testosterone and estradiol, this variant underlies the Sex-hormone transport trait.
Traits rs6259 reads
Gene
Reference databases
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