rs7193343
rs7193343 is a non-coding variant in/near the ZFHX3 (zinc finger homeobox 3) gene on chromosome 16q22, identified through genome-wide association studies of atrial fibrillation. The T allele is associated with modestly increased risk of atrial fibrillation, with an odds ratio around 1.17-1.20 in European-ancestry cohorts (association not replicated in Asian cohorts), through effects on ZFHX3's regulatory role in cardiac tissue that are not yet fully defined. It contributes, alongside PITX2 rs2200733 and KCNN3 rs13376333, to polygenic atrial fibrillation risk scoring.
Traits rs7193343 reads
Gene
Reference databases
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