FKBP5
FKBP5 encodes FK506-binding protein 5, a co-chaperone that binds the glucocorticoid receptor complex and regulates its sensitivity to cortisol, acting as a negative-feedback brake on the hypothalamic-pituitary-adrenal (HPA) stress axis. Variants such as rs1360780 alter FKBP5 induction after glucocorticoid exposure, changing how quickly cortisol signaling resets after stress. This variability places FKBP5 within the stress-response and cortisol-signaling pathway and has been linked in the research literature to differences in stress reactivity and resilience.
Traits FKBP5 shapes
Markers (rsIDs)
Reference databases
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