GIPR
GIPR encodes the glucose-dependent insulinotropic polypeptide receptor, a class B1 G-protein-coupled receptor expressed on pancreatic beta cells, adipose tissue, bone, and brain that is activated by the gut hormone GIP after meals to boost glucose-dependent insulin secretion and regulate fat storage and bone homeostasis. It is a target of dual GIP/GLP-1 medicines such as tirzepatide. The rs1800437 variant has been studied for nausea and vomiting on tirzepatide, not for weight-loss efficacy, and no prescribing guideline uses it.
Traits GIPR shapes
Markers (rsIDs)
Reference databases
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