rs1800437
rs1800437 is the GIPR Glu354Gln (E354Q) missense variant in the glucose-dependent insulinotropic polypeptide receptor gene. The Gln354 allele produces a partial loss-of-function receptor with increased desensitization and reduced downstream signaling in response to GIP. Because GIPR is a target of dual GIP/GLP-1 agonist drugs such as tirzepatide, this variant is studied as inherited context for weight-loss response and side-effect signals with GLP-1-class medications.
Traits rs1800437 reads
Gene
Reference databases
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