Gene

IRF4

IRF4 encodes a transcription factor that also helps regulate pigment-cell genes. rs12203592 lies in an IRF4 enhancer and is strongly associated with freckling in European-ancestry studies. The marker changes average tendency, not a person's exact freckle count.

Traits IRF4 shapes

Freckling tendency

Markers (rsIDs)

rs12203592

Reference databases

HGNC gene symbol report: IRF4
NCBI Gene: IRF4

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.