Marker

rs12203592

rs12203592 is a GRCh38 C/G/T regulatory marker in an IRF4 enhancer. In multiple European-ancestry studies, each T copy was linked to higher average freckling. T disrupts TFAP2A binding and reduces IRF4 and TYR expression, but the genotype does not determine a personal freckle count. The unstudied G allele is outside the reviewed freckling map.

Traits rs12203592 reads

Freckling tendency

Gene

IRF4

Reference databases

dbSNP: rs12203592

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.