Gene

MEIS1

MEIS1 encodes a homeobox transcription factor important in early neurodevelopment and in central nervous system iron regulation and circadian gene expression. GWAS have consistently linked MEIS1 variants to restless legs syndrome risk and to sleep-stage (REM/NREM) architecture, likely reflecting its role in dopaminergic and iron-handling pathways implicated in these sleep phenotypes.

Traits MEIS1 shapes

REM vs deep-sleep balance (MEIS1)
Restless legs syndrome risk

Markers (rsIDs)

rs113851554

Reference databases

HGNC gene symbol report: MEIS1
NCBI Gene: MEIS1

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