SIX1
SIX1 encodes a homeodomain transcription factor of the SIX gene family that directs organ development, including the eye, ear, kidney, and skeletal muscle, during embryogenesis. SIX1 lies immediately adjacent to SIX6 (a gene critical for optic nerve and retinal development) on chromosome 14, and this shared SIX1/SIX6 locus, tagged by variants such as rs10483727, is one of the most consistently replicated genome-wide association signals for optic-nerve cup-to-disc ratio and primary open-angle glaucoma risk.
Traits SIX1 shapes
Markers (rsIDs)
Reference databases
How Biome reads this
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