rs10483727
rs10483727 is a non-coding tag SNP at the SIX1/SIX6 locus on chromosome 14, near genes that regulate optic nerve and retinal ganglion cell development. Genome-wide association studies link the variant to primary open-angle glaucoma (odds ratio about 1.32) and to vertical cup-to-disc ratio, a heritable measure of optic nerve cupping used in glaucoma risk assessment, with the association strongest in East Asian and European cohorts.
Traits rs10483727 reads
Gene
Reference databases
How Biome reads this
Biome's at-home DNA test reads this directly from one saliva sample, alongside 650,000+ other markers.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.