Gene

TPMT

TPMT methylates parts of the thiopurine pathway and changes active and methylated metabolite patterns. Decreased activity can raise active-metabolite exposure and severe blood-cell toxicity risk. TPMT does not simply measure whole-drug clearance or set a safe dose by itself; clinicians also use NUDT15, the treatment protocol, and blood tests.

Traits TPMT shapes

Thiopurine drug clearance

Reference databases

HGNC gene symbol report: TPMT
NCBI Gene: TPMT

How Biome reads this

Biome's whole-genome test reads this from one saliva sample, alongside all 3.2 billion letters of your DNA.

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.