TraitHigh for TPMT activity, blood-count toxicity, and CPIC guidance
Thiopurine drug clearance
Thiopurine drug clearance is a genetic trait Biome reports in its medication response panel: TPMT affects how much active medicine can build up with azathioprine, mercaptopurine, and thioguanine. Lower activity can raise the risk of dangerously low blood counts.
- Category
- Medication response
- Markers
- TPMT diplotype and predicted activity
- Strength of evidence
- High for TPMT activity, blood-count toxicity, and CPIC guidance
- DNA-test coverage
- Stronger with whole genome
Genes
How Biome reads this
Biome's whole-genome test reads this from one saliva sample, alongside all 3.2 billion letters of your DNA.
Biome DNA test →This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.