rs115366859
rs115366859 is an intronic variant in GC on chromosome 4, the gene encoding vitamin D-binding protein (DBP), the primary plasma carrier of 25-hydroxyvitamin D. In a gene-by-environment GWAS of over 338,000 UK Biobank participants that incorporated satellite-derived ambient UVB exposure, it showed the strongest gene-by-UVB interaction effect among newly identified variants, indicating its influence on circulating 25-hydroxyvitamin D depends on an individual's sun exposure rather than acting uniformly. It is used, alongside PDE3B, PSMA1, COPB1, CALCB, and BMAL1/ARNTL loci, to characterize how vitamin D genetics may interact with sun exposure, season, and supplementation.
Traits rs115366859 reads
Gene
Reference databases
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