rs1799963
rs1799963 is the F2 (prothrombin) 20210G>A variant, a single-base substitution in the gene's 3' untranslated region rather than a coding change. The A allele increases recognition of the 3' cleavage/polyadenylation signal, boosting mRNA processing and stability, which raises circulating prothrombin levels and thrombin generation. Heterozygous carriers have roughly a 2- to 4-fold increased risk of venous thromboembolism (DVT/PE) compared with non-carriers, and this dataset pairs it with Factor V Leiden (F5 rs6025) to assess hereditary thrombophilia risk.
Traits rs1799963 reads
Gene
Reference databases
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