Marker

rs2066844

rs2066844 is the NOD2 Arg702Trp (R702W) missense variant, one of three principal NOD2 coding variants (with rs2066845/Gly908Arg and rs2066847/Leu1007fsinsC) that are the strongest known single-gene risk factors for Crohn's disease. The variant lies in the leucine-rich repeat region NOD2 normally uses to sense bacterial muramyl dipeptide, impairing this innate-immune recognition function. It contributes to inflammatory bowel disease genetic risk alongside IL23R and ATG16L1 variants.

Traits rs2066844 reads

Inflammatory bowel disease risk

Gene

NOD2

Reference databases

dbSNP: rs2066844

How Biome reads this

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This page is for educational purposes only and is not medical advice. It is not intended to diagnose, treat, cure, or prevent any disease. Genetic results describe tendencies and predispositions, not diagnoses. Always consult a licensed clinician before making decisions about your health, medications, or supplements.