rs2282679
rs2282679 is a common intronic variant in GC, the gene encoding vitamin D binding protein (group-specific component), which transports vitamin D metabolites in blood. It is not itself a coding change but is a near-perfect proxy for the missense GC variant rs4588, and tags reduced circulating levels of 25-hydroxyvitamin D. The minor (C) allele is associated with lower serum vitamin D and higher odds of vitamin D insufficiency, particularly during low-sunlight months, and is used together with CYP2R1 rs10741657 and DHCR7/NADSYN1 rs12785878 to assess genetic vitamin D status.
Traits rs2282679 reads
Gene
Reference databases
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