rs602662
rs602662 is a missense variant in FUT2 (a substitution affecting residue 258) that sits in strong linkage disequilibrium with the enzyme-inactivating rs601338 (Trp154Ter) nonsense mutation, so it largely tracks the same secretor/non-secretor status. Independent of that linkage, rs602662 is among the SNPs most strongly associated with plasma vitamin B12 concentration in genome-wide association studies, since non-secretor genotypes carry higher circulating holo-haptocorrin-bound B12 than secretors. It is used alongside TCN2 rs1801198 to characterize B12 transport and status.
Traits rs602662 reads
Gene
Reference databases
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