rs762551
rs762551 is a C>A regulatory variant in intron 1 of CYP1A2 (also called CYP1A2*1F, or the -163C>A/-164A>C variant) rather than a coding change. The A allele preserves the enzyme's inducibility by substrates such as cigarette smoke, producing higher CYP1A2 activity and faster caffeine clearance in smokers, whereas the C allele is associated with lower inducibility and slower caffeine metabolism; effects are most pronounced in smokers and heavy coffee drinkers. It is used to characterize whether an individual tends to clear caffeine quickly or slowly.
Traits rs762551 reads
Gene
Reference databases
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